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InVivoSIM anti-human TROP-2(Sacituzumab Biosimilar)

更新時(shí)間:2025-07-14   點(diǎn)擊次數(shù):66次

InVivoSIM anti-human TROP-2 (Sacituzumab Biosimilar) clone: Sacituzumab (Catalog #SIM0051)

產(chǎn)品中文名稱(chēng):InVivoSIM 抗人TROP-2(Sacituzumab 生物仿制藥)抗體,克隆:Sacituzumab(目錄號(hào) #SIM0051)

SIM0051.jpg

(產(chǎn)品示例圖)

 

Key features:

▲ Sacituzumab is a humanized IgG1κ against human trophoblastic cell surface antigen 2 (TROP-2).

▲ TROP-2 is a cell surface receptor, and its ligands include claudin-1, claudin-7, cyclin D1, and IGF-1.

▲ TROP2 is an upcoming tumor antigen that is expressed in glioblastoma, pancreatic carcinoma, and all breast cancer subtypes. TROP-2 is a cellular marker of trophoblastic stem cells.

▲ TROP2 transduces calcium signals and drives tumor proliferation, invasion, and metastasis.

▲ The tumor cell-specific expression of TROP-2 makes it an ideal target for cancer immunotherapy.

▲ Sacituzumab is used for making antibodydrug conjugates (ADC) and also to eradicate cancer cells.

 

Application: in vitro functional assays, in vivo functional assays, Antibody-drug conjugate synthesis, ELISA, Western blot, Flow cytometry

cytometry Research Area: Tumor Antigens, Cancer Biology

Related targets: EGFR, EPCAM (CD326), HER2/erbB2, PSMA, EphA2, CEACAM

 

主要特點(diǎn):

▲ Sacituzumab 是一種針對(duì)人滋養(yǎng)細(xì)胞表 面抗原 2(TROP-2)的重組人源化 IgG1κ 抗體。

▲ TROP-2 是一種細(xì)胞表面受體,其配體 包括 claudin-1、claudin-7、cyclin D1 和 IGF-1。

▲ TROP-2 是新興的腫瘤抗原,表達(dá)于膠 質(zhì)母細(xì)胞瘤、胰腺癌以及所有乳腺癌亞 型中。TROP-2 是滋養(yǎng)細(xì)胞干細(xì)胞的細(xì) 胞標(biāo)志物。

▲ TROP-2 傳導(dǎo)鈣信號(hào),并驅(qū)動(dòng)腫瘤的增 殖、侵襲和轉(zhuǎn)移。

▲ TROP-2 在腫瘤細(xì)胞中的特異性表達(dá)使 其成為癌癥免疫療法的理想靶點(diǎn)。

▲ Sacituzumab 用于抗體藥物偶聯(lián)物 (ADC)的合成,同時(shí)也用于消除癌細(xì) 胞。

 

應(yīng)用:體外功能實(shí)驗(yàn)、體內(nèi)功能實(shí)驗(yàn)、抗體藥物偶 聯(lián)物合成、ELISA、Western blot、流式細(xì)胞術(shù)

研究領(lǐng)域:腫瘤抗原、癌癥生物學(xué)

相關(guān)靶點(diǎn):EGFR、EPCAM(CD326)、HER2/erbB2、 PSMA、EphA2、CEACAM 

 

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